K-677 is one of the most popular compounds on the market right now. It’s more known for its online notoriety than its clinical research data.
You might also know MK677 as Ibutamoren or Nutrabol.
As we mentioned, there’s a lot of information available out there on this compound.
Most of it shows that MK-677 is great at boosting IGF-1 and growth hormone levels. There are also plenty of other benefits associated with MK-677 which we’ll explore in-depth throughout this review.
What is Ibutamoren?
Most online forums mention that MK-677 is a muscle building compound that you can buy over the counter to boost your growth hormone levels.
These discussions leave out a very important piece of the puzzle. Because only a few clinical studies have been conducted to corroborate these claims.
We are going to discuss all the available information on Mk677 (Ibutamoren).
This way, you can decide whether or not it is worth researching with.
To be clear, Ibutamoren doesn’t belong to the SARMs family. Just like with Cardarine and Stenabolic it’s just marketed as a SARM to make things easier.
One of the most notable claims made about Ibutamoren is that it can increase the secretion of growth factors-1 (IGF-1) and growth hormone (GH).
It does this by imitating the way the ghrelin hormone works. This allows it to bind onto one of the brain’s dedicated ghrelin receptors (GHSR). Once activated, GHSR then stimulates the production of the growth hormone in the brain.
|Compound Profile:||Recommended Dosage:||CAS Number:||Half-life:|
|MK-677 (Ibutamoren)||10 to 20mg per day||159634-47-6||6 hours|
It’s interesting to note that GHSR is especially present in the brain regions. This region functions like memory, biological rhythms, mood, pleasure, appetite, and cognition.
Naturally, MK-677 may have an effect on these functions as well, whether it’s to increase or diminish them.
What makes MK-677 so unique is the fact that it can increase GH levels. But it does not disrupt the action of other hormones in your body such as cortisol.
If it did, you’d experience side effects. These would include reduced immune function, impaired wound healing and a diminished ability to learn and memorize information.
Thankfully, that’s unlikely to happen with Nutrobal.
How Does MK-677 Work?
As mentioned, MK-677 works by imitating the activity of ghrelin. In case you’re wondering, ghrelin is a naturally occurring hormone.
It functions as a neuropeptide in the central nervous system. Mostly, this hormone is known for its ability to stimulate a ravenous appetite!
This is in addition to the regulation of energy distribution in the body. It also affects the way our bodies metabolize fat. It can also influence our ability to recover from conditions such as Type 2 diabetes and obesity.
When taken on its own, MK677 has the potential to boost HGH production without disturbing other hormones. Users also like the fact that Ibutamoren doesn’t suppress the body’s existing levels of growth hormones and testosterone, which is a huge bonus considering the benefits.
- Builds Muscle
MK-677 is popular for its anabolic properties. This enables it to promote the lean gains that most athletes are after. These effects can only be activated when Nutrobal is taken orally once per day.
That’s because it not only boosts IGF-1 levels but it increases growth hormone production as well. When taken together, these benefits can help you increase muscle size and strength while significantly reducing the amount of body fat you have.
A double-blind randomized controlled trial was conducted with 24 obese men over a period of two months and they were given MK-677 as a treatment. Within two months, the participants showed an increase in basal metabolic rate (BMR) and they had more lean muscle mass.
MK-677 doesn’t work the same way as a SARM, like for example LGD-4033, Ostarine, RAD-140 etc. It’s often compared to SARMs, but they are not the same and work differently.
- Prevents Muscle Wasting
Yet another double-blind randomized control trial study was conducted with eight food-deprived volunteers. In these participants, MK-677 was shown to reverse protein loss and muscle wasting that they’d experienced as a result of diet and lifestyle.
MK-677 was also shown to reduce the number of falls experienced by elderly patients with hip fractures. This randomized controlled trial helped the patients experience better gains while increasing muscle strength.
- Increases Bone Density
Studies show that GH can increase bone density by affecting bone turnover. The interesting thing is that the process starts by decreasing the bone turnover first before increasing it, which means it can take up to 12 months to see the results.
In a double-blind randomized controlled trial with 24 obese male participants, MK-677 was found to increase bone turnover as expected.
In another three double-blind randomized controlled trials, MK-677 was able to improve the body’s ability to build stronger bones in elderly adults aged 65 years and older. Another study with 292 post-menopausal women found that MK-677 can significantly improve bone strength through increased mineral density. This proved very helpful in preventing osteoporosis in postmenopausal women.
- Helps with Sleep
MK-677 was shown to improve the quality and quantity of REM sleep in both young and elderly participants of a double-blind randomized controlled trial study.
Aside from the scientific evidence, there’s plenty of anecdotal evidence to support this claim. Many users have experienced improved sleep as a result of taking MK-677.
We all know that sleep is an important part of the bodybuilding. It allows us to recover quickly and gain strength for the next training session.
Once we’re done with puberty, the body’s GH secretion levels decline drastically. However, taking MK-677 can remedy this problem because it can increase IGF-1 and GH levels.
This is based on a double-blind randomized controlled trial study which was conducted with 65 elderly men. The participants were given a daily dose of MK-677 and showed increased GH levels afterward.
Yet another double-blind randomized controlled trial study was conducted with 24 obese males and it showed the same positive results.
- Nootropic Effects
Since Ibutamoren can stimulate the ghrelin receptor, it may cause nootropic effects as well. With that said, there’s no empirical evidence to suggest that the compound has any effects on cognitive performance.
What we do know is that MK-677 can help improve brain function by indirectly influencing two mechanisms, namely:
- Through the increase of IGF-1 which helps boost learning ability and memory retention
- Through improved quantity and quality of REM sleep. Sleep is vital to ensuring optimal cognitive function.
A multicenter double-blind randomized controlled trial study conducted with Alzheimer’s patients tried to determine the compound’s effect on this disease. Unfortunately, the results were inconclusive, so no cure for Alzheimer’s yet.
- Prevents Growth Hormone Deficiency
By now, we know that MK-677 has the ability to boost the production of IGF-1, IGFBP-3 and the growth hormone to assist children that are struggling with hormone deficiencies. The great news is that MK-677 was able to achieve this without disturbing other hormones like cortisol, insulin, thyrotropin, thyroxine (T4), glucose and triiodothyronine (T3).
But it appears that the same cannot be said for adult patients. A double-blind randomized controlled trial with severely-GH deficient adult males found that in addition to improved IGF-1 levels, the participants experienced increased glucose and insulin levels. Suffice to say this was a rare instance of Ibutamoren actually disrupting other hormones.
- Heals Wounds
The growth hormone improves the body’s ability to heal wounds and rebuild damaged tissue. MK677 is a no brainer when it comes to wound healing. But, this particular benefit is based on anecdotal evidence rather than scientific study.
- Cures Hangovers
This is only based on subjective and anecdotal evidence, but there have been claims that MK-677 can actually cure hangovers.
MK-677 Side Effects
The most common side effects associated with MK677 include muscle pain and an increased appetite.
Some studies showed that participants had reduced insulin sensitivity and higher fasting blood glucose. These are the same results shown in people that have higher growth hormone levels.
Suffice to say, Ibutamoren typically exhibits mild to no side effects all save for one particular episode that stands out. In the study we mentioned above which featured elderly patients with hip fractures, MK-677 led to spikes in blood glucose, blood pressure and even a risk of congestive heart failure. As a result, the study had to be stopped because the patients that were experiencing these problems already had a history of heart failure.
That’s why it’s always a good idea to curtail carb intake and keep your insulin and blood sugar levels in check as much as you can. Taking MK-677 might help.
Of course, MK-677 is not recommended for cancer patients because it’s an anabolic substance that promotes GH and IGF-1 production.
It’s also ill-advised to take MK-677 if you’re Th 1 dominant for the same reasons mentioned above.
MK-677 is mostly available in capsule and liquid form. It’s recommended to take orally in daily dosages up to 25 mg. It’s up to you to split the dosage or take it all at once.
Although there are a lot of users who take a bigger dosage. We wouldn’t recommend you try that as higher dosages could expose you to serious adverse side effects.
It’s important that you start slow and slowly increase your dosage. So, for example, you can start off with 10mg of MK677 a day and up the dosage to 20-25mg a day.
MK-677 Cycle Example:
|2 months+||10 to 20mg per day|
Buy MK-677 (Ibutamoren)
It’s important that you buy MK-677 from a reputable source. A lot of vendors are known to underdose their products or worse, they don’t their products. We buy our MK-677 from Sarms4you because it’s the best quality out there.
There you have it!
Hopefully, now you know enough about MK-677 to use it wisely.
There’s no doubt that this compound works great at increasing muscle size and strength, and it’ll help you burn fat and shed weight without sacrificing your diet.
Feel free to try it out but make sure to use it in the recommended doses and only source it from a reputable online vendor or health shop.